@Antonio2969 I am guessing that you want to avoid local people booking to avoid potential ‘Party’ scenarios etc. ? As @Mike-And-Jane0 stated, Airbnb do not allow discrimination of any kind and I am unaware of any filter you can put in. However, you could have a minimum age requirement, a cap on guest numbers, tighten things up on your ID requirements and also have guests request or enquire about bookings rather than use Instant Book.
@Antonio2969 As long as you leave Instant Book turned off, you can screen each guest on a case-by-case basis. If you get a request that seems suspicious, you can decline it. But it's best not to be explicit about your reason, if it can possibly be construed as discrimination.