@Janna25 When I lived in the UK I would deliberately spend extra hours at my workplace to avoid walking home at the time when all the pubs closed. Of course there are binge-drinking cultures all over the place, but Britain's somehow feels more aggressive and competitive. I wouldn't say it's limited by age or gender, though I can certainly understand having extra wariness of groups of young men.
If you'd rather risk lower occupancy rates than deal with more pee and vomit, turning off Instant Book would be a good start. The initial correspondence with the guest is a much better indicator of what you can expect than the nationality, age, gender, etc.
Also, you mentioned that rules were broken but the only clear rule I can see on your listing is "no shoes inside." I'd suggest using more clear and specific language. Instead of "don't be too noisy," state which times are quiet hours (no amplified music, etc.). Instead of "take care of the place" (which doesn't really mean anything), communicate the cleaning tasks you expect guests to do before checkout (e.g. clean bathroom surfaces, wash dishes, remove trash). Instead of "no parties," state unequivocally that no unregistered guests are permitted to enter the property - and if necessary, back that up with video surveillance of the exterior door. Reinforce the "no smoking" with an instruction for the nearest place that guests can smoke outside the property.
You might also find it better for you or a co-host to personally check the guests in and out, rather than relying on the smart lock. That signifies that there are eyes on the house, and that it might be inspected before the guests depart. As long as you're renting a whole flat with a hot tub, you're going to get some hard-partying guests, but there's no reason you can't guide them toward leaving the place in good condition and mopping up their own pee.