@Maureen447, I'm also a home share host, and I have spent plenty of nights away. I don't advertise this because I don't want to attract people who think I won't be here, but often I will let them know after they have arrived that I will away for a night or two and check that they're okay with it. Most of the time they're delighted! They get a whole house for the price of a room. For example, my stove/oven and lounge are usually out of bounds for guests, but if I'm not going to be here, I tell them they are welcome to use these facilities. On rare occasions, I have been away when a guest arrives, and I simply send them detailed check in instructions - I've never had a problem with this.
One thing I'd advise that gives me peace of mind is that I have installed a lock on my bedroom door that can be locked from the outside. I can then stash any valuables in there, and it means that any weirdo guests can't go snooping around in there. Otherwise, I'm happy for them to have free range of the house.