I’ve hosted lots of guests who were new to Airbnb, and they have all been great guests. Better than some experienced guests with 5 star reviews.
When receiving a request from a ”newbie”, I first consider the tone of the initial message. Then reply with maybe a question or two about the guest/stay, and or offer some information that they need to respond to. Like ”did you notice my place is 45 min from the city centre by bus/train”, or ”will you be ok with the sleeping loft”.
I feel it is not so important WHAT I ask (I don’t need to know their profession, or where they live). I just want to make them send me another message, to get a feeling about what kind of guest they might be, and their expectations.
Good luck!