Hi Deirdre,
My space is a small one, so I use a closet to store supplies with a deadbolt combination lock like this one: Schlage BE375 CAM 619 Touch Camelot Deadbolt, Electronic Keyless Entry Lock, Satin Nickel https://a.co/d/5Wn0G3c. (My guests have drawers and hooks/hangers available, but rarely use them.)
I have seen whole-house spaces that have combination locks on EVERY bedroom/bath door (so that, if only 1 bedroom is needed, guests have access to ONLY the linens provided for THEM, and they leave the other 2 or 3 bedrooms alone... In my mind this would save hosts a LOT of laundry and cleaning, supplies, and such, and the savings would pay for the locks in a hurry.
I have asked people who clean the houses, and you would be surprised at how many people, even it they only require ONE bed, have to use EVERY bed in the house.
Blessings and best of luck!
Sonya