@Elizabeth3327. Hi Elizabeth, I have a studio listing. When I did my renos I considered closing off the bedroom but didnt. Its been a real plus because both heat and cool circulate better. Trying to fit more people in, just to get the occupancy up may not be the best strategy either. Noise insulation is essential in your case.
As you are hosting mid term I'd consider investing in a combo washer/dryer, even if you need to rejig a little (you just dont want unnecessary guest interaction when its your family home). Anywhere they can hang their washing? You mention storage under stairs- will that be for your family? What storage do you propose to offer guests if losing the entire bedroom? Where is new entry and who gets the porch area in front of the current bedroom- or is that being closed off as well? Private, exclusive outdoor areas are in high demand.
Hope this helps.