If I understand your description, you have a two story house that is going to be renovated and you are wanting input about making two studios or 4 bedrooms. Right?
I don't know your market, but your description of the closness to a major airport suggests you expect most of your guests to stay a single night rather than to remain in the area. Is that correct?
I assume you will not be residing in the house as well so you are looking to be a remote manager/host. Here are my thoughts: 4 bedrooms turning over daily is a great deal of work. It is what hotels do and are staffed for. If your area begins to restrict short term rentals, as is occurring in many places throughout the world, having 4 bedrooms and one bath for short term rental is "putting all your eggs in one basket".
If you have 2 studio apartments , you would appeal to both single night and multi night guests. Also, you could more easily convert one or both to long term rentals.
Perhaps a middle ground is to divide into one self-contained studio and two bedrooms with a shared bath. This allows a middle ground for 3 individual short term rentals while still allowing long term option for the studio and short term for the 2 bedrooms. Just a thought.