@Jordin3 Who do you see as your target market? That has a lot to do with what sort of bed configurations to go with.
Being close to a major airport in a big city, I could imagine you getting bookings from travelers who have layovers, overbooked flights, who have early morning flights, but live a couple hours away, so would want to spend the night close to the airport.
In that case, two twins in the second bedroom would give more flexibility to travelers who may just be friends or business associates, who wouldn't be sharing a bed.
Two twins, as long as they have felt pads under the legs or are otherwise easy to move, can also be pushed together to make a king size bed.