@Lizzie My cabin is in a very rural county in Colorado, but in this day and age, with modern communications and transportation, there aren't too many very remote and desolate places remaining.
We are located on a gravel road about 20 minutes from the nearest town, which has a population of about 1,200 but luckily we found a great cleaning service and have pretty reliable Internet, which helps immensely.
Some of my advice would be (many of these could apply in urban areas as well):
~Give very detailed directions including mileage points for each turn.
~Highlight in the listing and advise guests before confirming of any amenity limitation such as hot water.
~Educate guests about wildlife and weather issues.
~If one lives in a dry area, advise heavily about fires and smoking.
~Perhaps advise guests of distances, which will be longer in rural areas. I had one guest say something (not too negatively) about the 20 minute drive to the grocery store, which seems quite short to me, but apparently coming from the city he thought it long. But, you might mention to them to get gas and groceries before coming, that sort of thing.
If hosting remotely in a rural area:
~Make sure you first and foremost find a good, reliable cleaning service that can also look out for things like leaks or other issues with the home.
~If Internet is available:
~Install a heating source or thermostat which you can control remotely in the winter to avoid pipes freezing.
~Install a smart lock.
~Install a security camera, to check number of guests, pets and for security.