@Peggy301,
You can create two listings for the same place, each with a different configuration (e.g., 2 bed/2 bath and 4 bed/3 bath) and link the calendars. If one configuration is booked, the calendar of the other configuration will be blocked to avoid potential double booking. Here is the link with the directions: https://www.airbnb.com/help/article/1864/how-do-i-link-airbnb-calendars-for-multiple-listings.
Please note that the blocking will only occur between the primary listing and one secondary listing. You may link more listings, but a booking made on a secondary listing will not block the calendar of another secondary listing, and you may end up with a double booking.
@Mike-And-Jane0