@David9849 What does your zoning permit? What kind of neighborhood are you in? Single homes or homes that have been converted to apartments? Are you permitted to lock off one floor from another without an outside fire stair?
If on a septic system, the size of the system will determine the number of bathrooms. However, a bathroom should be on each floor. If you use the first floor as a "venue for small gatherings", you will want an en suite as well as a powder room.
If you can put a bathroom/kitchenette on the third floor, you could rent that space to a "caretaker/co-host" and then rent the other two floors separately. Again, what will your zoning permit.