Sarah, YES OF COURSE, you can do anything you wish.
This is Airbnb. It is your house, your rules.
You will be at a disadvantage to other hosts, so you would have to make it up with pricing and incredible marketing.
You would have to be very upfront about your expectations and methods to enforce ( no wifi 8 - 5?, No heat?, No water?)
One guy only accepts one day stays and has a late checkin and an early check-out. Very intrigueing.
A less formal way to get them out of your house is to make your house more inhospitable. No TV. No kitchen access. Host a book club. Practice the piano.
Have you every noticed how no one ever uses a hotel's lobby sitting area? They make it "seem" attractive with out it being hospitable. And like other people have suggested, supply them with activities nearby.
I have been blessed with guests who stay many days and never stay at my house during the day.