@Silvia1788
If you do the cleaning yourself, definitely each week and do the other cleaning in the room at the same time.
Arrange with your Guest what date / day and time you will be doing this and suggest they pop away any personal items they may like to tuck away before you undertake the cleaning.
Most Guests appreciate clean linen and a clean room and after a week dust and grime does start to settle in, those with Asthma for example can have problems flare up with dust.
Open communication is the best way to go with your Guest in advance.
All the best