@Nancy1235 As you're renting out an entire house, there's unfortunately no way to directly police what people do in your home. So you have to establish effective boundaries that work better in your absence.
Closets, rooms, and storage areas that you don't want guests to go through should have a secure lock installed on them. A post-it note does not constitute a lock.
Since having "no smoking" in your default rules hasn't gotten the message across, try being more assertive about this. Indicate in the listing where the nearest place people are permitted to smoke is, and reinforce during the check-in that your house is smoke-free (one host cleverly included NOSMOKING in her wifi password).
Above all, you'll need to have more text and photos in your listing and a more thorough screening process, because it's clear from reviews that your home is suitable for a narrower range of guests than it would appear from the listing. You should make it much more clear that the home is your primary residence, contains your belongings, and features limited storage space and kitchen use. Therefore, your target guests are going to be non-smoking visitors on short stays who travel lightly and don't require kitchen use. It's OK to mention that upfront in the listing, and also to discuss before accepting a Request to make sure that it's an appropriate fit.