Hello @Renae5,
There isn't a way to do that. Once the weekend option is set it applies to all reservations.
I tried setting a two week minimum for weekends for my listing and then setting a 1 night minimum, using specific dates, for one weekend but it didn't work. The "Fridays and Saturdays" setting overrode the "specific dates" setting.
Using specific dates to set a 1 night minimum for Sept 22 to 24 when I have 2 nights set for weekends didn't work. My listing didn't show in a 1 night search for Sept 22 or Sept 23.
Steve.