I agree with the other hosts that have commented. Do you really want to vacate your home and find somewhere else to stay ?
What would you do with all the valuables in your home and your personal items in the main bedroom if you were to do this?
I wouldn't do this and I am sure most experienced hosts wouldn't do this either.
You have to ask yourself why a couple would want to book such a large space when it would be much cheaper for them to get a one bedroom place if they want privacy.
I would just decline the request.
If you do want to go ahead you need to think about what price you would want to charge to let out a whole space and send them a special offer (you need to allow for your costs of staying elsewhere).