I'm not quite clear what you are asking - could be one of two questions so I’ll answer accordingly. I note you have Instant Booking on your listing
1) Are you asking if you can block some dates in your calendar? If so yes, click on link for guide - https://www.airbnb.co.uk/help/article/447/how-do-i-manage-my-availability-on-my-calendar
2) Are you asking if you can have a combination of Instant Booing on some days and the option to Request to Book on other days? If so, then the answer is no. You either have Instant Booking or Request to Book.
Hope one of those answers covers you question.
BW, Ama