No direct experience, but a few thoughts...
Will you set up additional listings: one for the entire property, another for your own room as a standalone - in addition to the room you already advertise.
If so the entire property rental is not a problem..as guests would take the entire unit and all bedrooms.
Individual rooms - you would need to be very clear with people booking that there are other guests and no owner living on site. I would share some of your concerns re the behaviour of one set of guests annoying others - plus if damage is done, how you do know who did it...lots of questions...
Just wonder if it is too difficult and the answer is to rent the entire property as one unit and price accordingly after the first two guests?